منابع مشابه
Serum neurofilament light chain in relapsing-remitting MS
MS is a chronic disease of the CNS, well recognized for its diverse clinical presentations and outcomes. Clinicians continue to struggle to predict shortor long-term prognosis of persons affected by MS, to predict response to the growing array of diseasemodifying treatments available, and to identify persons at risk of serious adverse events from those treatments. As such, valid, reliable, and ...
متن کاملNeurofilament light chain predicts disease activity in relapsing-remitting MS
Objective To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). Methods A cohort of 85 patients with RRMS were followed for 2 years (6 months without disease-modifying treatment and 18 months with interferon-beta 1a [IFNB-1a]). Expanded Disability Status Scale was scored at baseline and every 6 ...
متن کاملIncreased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases
OBJECTIVE Neuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into cerebrospinal fluid has shown encouraging results as a biomarker for neurodegeneration. This study aimed to validate the quantification of the Nf light chain (NfL) in blood samples, as a biofluid source easily accessible ...
متن کاملNeurofilament light chain
Objective: To test blood and CSF neurofilament light chain (NfL) levels in relation to disease progression and survival in amyotrophic lateral sclerosis (ALS). Methods: Using an electrochemiluminescence immunoassay, NfL levels were measured in samples from 2 cohorts of patients with sporadic ALS and healthy controls, recruited in London (ALS/control, plasma: n 5 103/42) and Oxford (ALS/control,...
متن کاملA comparative study of CSF neurofilament light and heavy chain protein in MS.
BACKGROUND There is a lack of reliable biomarkers of axonal degeneration. Neurofilaments are promising candidates to fulfil this task. We compared two highly sensitive assays to measure two subunits of the neurofilament protein (neurofilament light (NfL) and neurofilament heavy chain (NfH)). METHODS We evaluated the analytical and clinical performance of the UmanDiagnostics NF-light(®) enzyme...
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ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2019
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000601